To confirm this result and broaden the panel of tested cytokines, the effect of IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-15, IL-23, IFN-α2a, IFN-γ, TNF-α and GM-CSF upon tumor cells lines sHLA-E production was tested. The gene discussed is IL4; the disease is neoplasm.