APP and early-onset autosomal dominant Alzheimer disease: Some examples include: ataxin 7 (spinocerebellar ataxia type 7; [37]), ataxin 3 (Machado-Joseph disease; [36], [58]), amyloid precursor protein APP (Alzheimer's disease; [59], [60], [61], [62]), prion protein (Creutzfeldt-Jakob disease; [63]), and huntingtin (Huntington's disease; [40], [42], [64], [65], [66]) and the Cu/Zn superoxide dismutase gene SOD1 (hereditary amyotrophic lateral sclerosis ALS; [40], [44], [45], [46], [67], [68], [69]).