The frequency of B-Raf and PIK3CA mutations in colorectal tumours has been estimated between 10 and 17% (Davies et al, 2002; Smith et al, 2002; Yuen et al, 2002; Calistri et al, 2005; Oliveira et al, 2007) and between 10 and 25% (Samuels et al, 2004; Velho et al, 2005; Nosho et al, 2008), respectively. Here, PIK3CA is linked to colorectal neoplasm.