V600E mutations in B-Raf are the most prevalent and therefore the most commonly analysed mutations in colorectal tumours (Davies et al, 2002; Yuen et al, 2002), whereas exons 9 (codons 542 and 545) and 20 (codons 1023 and 1047) have been shown to harbour ∼80% of all PIK3CA mutations (Samuels et al, 2004). Here, PIK3CA is linked to colorectal neoplasm.