In conclusion, Hoxc8 mRNA expression in human pancreatic cancer cell lines was inversely related to their capability to grow in the liver of nude rats and successful down-regulation of HOXC8 expression caused increased proliferation, migration and colony formation in Suit2-007, Panc-1 and MIA PaCa-2 PDAC cells, respectively. The gene discussed is HOXC8; the disease is pancreatic neoplasm.