We then examined the relative contribution of p53 and Ki67 to the updated classification of the 96 LB tumours: 57 of 96 (59.4%) were p53−/Ki67+, 19 (19.7%) were p53+/Ki67−, 12 (12.5%) were p53+/Ki67+ and 8 were p53−/Ki67− (HER2+). This evidence concerns the gene MKI67 and neoplasm.