First, UCP2 overexpression and diminished ROS levels in colon cancer cells interfere with post-translational phosphorylation of p53 by stress-activated protein kinases at the critical Ser15, Ser33 and Ser46 residues of its NH2 transactivation domain (Derdak et al, 2008). Here, UCP2 is linked to malignant colon neoplasm.