Interestingly, a recent study comparing microRNA expression profiles between paediatric YSTs and germinomas identified significant upregulation of all members of the miR-29 family (miR-29a, miR-29b and miR-29c) in germinomas (P=0.0001) (Murray et al, 2010), which correlates with the level of expression of DNMT3A and DNMT3B in the two subtypes of GCT. This evidence concerns the gene DNMT3A and germinoma.