In this paper, we report the Annexin V-fluorescein isothiocyanate (FITC) apoptosis assay test and in vivo animal test results of PSi in combination with NIR laser to investigate the ability of PSi to kill cancer cells as well as the death modes of cancer cells and the ability of PSi to inhibit the growth of tumors, respectively. The gene discussed is ANXA5; the disease is cancer.