Coincidentally, among HpSC-HCC tissues, miR-181 is found to be up-regulated and functions in promoting stemness by targeting hepatic transcriptional regulators of differentiation, such as CDX2 and GATA6, and nemo-like kinase (NLK), an inhibitor of Wnt/β-catenin signaling [73]. Here, NLK is linked to hepatocellular carcinoma.