Though the role of Akt in HCC is not confirmed, its activation is interestingly linked to more aggressive tumors in HCC [70] and an activation of β-catenin signaling in intestinal stem cells, suggesting that the two oncogenic pathways: PI3K/PTEN/Akt and Wnt/β-catenin may be interconnected to promote stemness and carcinogenesis [71]. This evidence concerns the gene PTEN and hepatocellular carcinoma.