TCF4 and hepatocellular carcinoma: The results showed that Tcf4 specifically bound to both amplicons in the miR-181a-2/miR-181b-2 promoter (figure 4C), indicating that the miR-181a-2/miR-181b-2 transcript is a direct transcriptional target of Wnt/β-catenin canonical signaling pathway in HCC.