PLOD1 and ovarian carcinoma: Of particular interest was the result demonstrating that LH dramatically activates the expression of the interleukin-6 gene (IL-6) (33↑), a pleiotropic cytokine that is assumed to be involved in ovarian carcinogenesis and may induce signaling pathways such as toll-like receptor, NOD-like receptor, cytosolic DNA-sensing, and Jak-STAT [35,36], which, in this sense, may indicate a potential therapeutic target for treating ovarian cancer.