ETS1 and melanoma: The P-T38/total ETS-1 ratio might tune the ETS-1/miR-222 loop in melanoma, a hypothesis that, beside promoter luciferase results, appears to rely on the concordant increment of P-T38-ETS-1 and miR-222 in PMA-treated Me1007 and A375M melanomas (Figure 5A,B) and on the direct correlation between the endogenously produced P-T38-ETS-1 and miR-222 in melanoma progression.