Our data confirm that, in metastatic melanomas, the ERK constitutive signaling activates c-JUN (Lopez-Bergami et al., 2007) and P-T38-ETS-1 (Yang et al., 1996), which in turn seem to cooperate towards miR-221/-222 activation (Figure 5) (Garofalo et al., 2009). Here, JUN is linked to melanoma.