Of note, the increment of miR-222 observed in the A375M metastatic melanoma after a 2-h PMA treatment was coupled with a simultaneous activation of P-T38-ETS-1, whereas the constitutive high expression of c-JUN appeared unmodified, thus suggesting that a higher P-T38/ETS-1 ratio is an essential step for miR-222 regulation and, consequently, melanoma malignancy (Figure 5). Here, JUN is linked to metastatic melanoma.