FGF2 and melanoma: Besides that, and possibly more importantly, we focused on the functional role of ETS1, bearing in mind that in melanoma, basic fibroblast growth factor (bFGF) constitutive activation is the main initiating factor of the MAPK-ERK-Ets1/2 signaling cascade (Carè et al., 1996; Squarzoni et al., 2011).