ETS1 and melanoma: Since we evidenced a direct relation between miR-221/-222 levels and the P-T38 form of ETS-1 in melanoma progression (see Figure 3A), we hypothesized that this regulation could be achieved through a miR222-ETS-1 loop, where miR-222 diminished the ETS-1 level, but the residual P-T38 ETS-1-activated fraction was in turn able to induce miR-222 transcription.