ETS1 and non-small cell lung carcinoma: Considering that in non-small cell lung cancer and hepatocarcinoma cells c-JUN has been involved in miR-221/-222 activation (Garofalo et al., 2009), it is also important to point out the capability of ETS-1 to associate and cooperatively bind with the AP-1 transcription complex to regulate gene expression (Chang et al., 2003).