Nevertheless, mice with targeted disruption of the MYOC gene (Myoc−/−) were: (i) viable; (ii) fertile; (iii) without any discernible phenotype; (iv) with a normal IOP, indicating that POAG is not caused by MYOC haplo-insufficiency but, might be due to a gain of function [60]. This evidence concerns the gene MYOC and open-angle glaucoma.