Increasing CIN70 quartile correlated with higher risk breast cancer histopathological features including larger tumour size (Figure 2B, p < 0.0001) and the proportion of patients with ER negative (Figure 2C, p < 0.0001) or HER2 positive (Figure 2D, p < 0.0001) breast cancer. The gene discussed is ESR1; the disease is neoplasm.