ESR1 and neoplasm: Consistent with the results obtained with the CIN70 signature, we observed that tumours of higher grade (Figure 2A, p < 0.0001), larger size (Figure 2B, p = 0.0008), ER negative (Figure 2C, p < 0.0001) or HER2 positive (Figure 2D, p < 0.0001) status are enriched in the GU group.