KCNMA1 and obesity due to melanocortin 4 receptor deficiency: The G-allele of rs2116830, located in intron 28 of the gene Potassium channel, calcium activated, large conductance, subfamily M, alpha member (KCNMA1) on chromosome 10, showed consistent effect direction and significant allelic association with obesity in the French cohort 5 comprising morbidly obese adults and population-based adult control subjects (P = 0.0017), but not in the German cohort 6 comprising morbidly obese youth and adult lean controls (P = 0.35) (Table 3, Figure 2A).