We have identified one new susceptibility locus for obesity near KCNMA1 (rs2116830) and confirmed association with BDNF (rs988712) [8], by GWA analysis in a limited sample of morbidly obese and lean adults This study was followed up by genotyping of five additional European case-control cohorts. The gene discussed is KCNMA1; the disease is obesity due to melanocortin 4 receptor deficiency.