With these findings, it is tempting to hypothesise, as to why overexpression of ALDH1A1 correlates with a more favorable clinical outcome: assuming that conventional cytotoxic therapy aims mainly at the proliferating, differentiated cellular fraction, it can be conjectured that overexpression of ALDH1A1 is associated with a biological type of tumour which is more prone to chemotherapy. The gene discussed is ALDH1A1; the disease is neoplasm.