ESR1 and breast neoplasm: The majority of ER-positive breast tumors overexpressing 14-3-3ζ were of the luminal B subtype, tumors with a poorer outcome compared with luminal A. Consistent with this, comparative genomic hybridization analyses have indicated that one of the most recurrent alterations in luminal B tumors is gain/amplification of the 8q region that harbors 14-3-3ζ (8q22) [36].