GPT and steatosis: Up to 3.5 years of treatment with exenatide b.i.d. or 1 year with exenatide once weekly improved alanine transaminase (ALT) and aspartate aminotransferase (AST), measures of hepatic function that are commonly used surrogates of liver inflammation/steatosis.28,79,80 Exenatide b.i.d. treatment has also been demonstrated to reduce liver fat content in individual patients.