Recent molecular analysis of a large panel of SSs provided new insights into the origin of SS, with oncogenic mutations in either FGFR3 (encoding fibroblast growth factor receptor 3) or HRAS (encoding v-Ha-ras Harvey rat sarcoma viral oncogene homolog) present in about 25% of SS specimens [8]. The gene discussed is FGFR3; the disease is synovial sarcoma.