Pairwise comparisons between tumours of different sizes all showed higher AT1R expression in irbesartan-insensitive tumours (AT1RHI) compared to irbesartan-sensitive tumours (AT1RLOW) (small tumours: 3 vs 2, P = 0.002; medium tumours score: 4 vs 2, P < 0.0001; large tumours: 4 vs 2, P < 0.0001 respectively, Mann-Whitney U test). The gene discussed is AGTR1; the disease is neoplasm.