GATA4 and Hypertension: It has been well-established that hypertension and stimulation with isoproterenol, phenylephrine, endothelin or other hypertrophic signals can activate GATA-4 through the MEK/ERK pathway to promote GATA-4 serine105 p38 phosphorylation for higher binding of GATA-4 on the specific promoter region to increase the transcriptional activity [15,16].