Various studies have shown an association between depression and cardiovascular diseases.[3] High sensitivity CRP, which is considered as an independent risk factor for coronary artery disease and a marker for systemic inflammation, is reported to be increased in depression.[3, 4] Depression is associated with immunological changes, and also, it is possible that depression may affect the development of coronary disease through systemic inflammation.[5]. The gene discussed is CRP; the disease is depressive symptom measurement.