Even after normalizing to total BALF protein levels, BALF IGF-1 was significantly higher in tumor-bearing animals than naïve controls (1.81 ± 0.33 vs. 0.95 ± 0.36 pg IGF-1/ug BALF protein, respectively, P < 0.01, mean ± SD), suggesting that more IGF-1 is produced in the lungs of tumor-bearing mice. This evidence concerns the gene IGF1 and neoplasm.