Therefore, our finding of high levels of serum GGT as an independent predictor for Ang-2 levels in type 2 diabetes mellitus could explain the association of type 2 diabetes and Ang-2 and further supports the hypothesis that therapeutic strategies for reduction of oxidative stress in diabetes mellitus might lower the incidence of micro-and macro-vascular complications [35,36]. This evidence concerns the gene ANGPT2 and diabetes mellitus.