RYR2 and cancer: The hypermethylated genes include FLJ25477, ITGA4, DAB2IP, KCNQ5, ZNF625, C1orf165, PRKAR1B, MDFI, C2orf32, RYR2, FLI1, RIC3, TRH, VGCNL1, EYA4 (for q-PCR validation we selected the genes from this list) and the hypomethylated genes include IL21R and PI3. It may be noted that DAB2IP is a known tumor suppressor gene that has been reported to be associated with other cancers [9,24,25]; ITGA4 is also reported to be required for lymphangiogenesis & tumor metastasis [26].