Kyphoscoliotic type of EDS is diagnosed by abnormally elevated ratio of urinary lysyl pyridinolines to hydroxylysyl pyridinoline crosslinks and can be confirmed by mutation analysis of PLOD1. Our results on LP/HP ratios indicate that the ratio is highest in the age group 0-4 year and subsequently decreases, however remains significantly elevated when compared to normal controls. The gene discussed is PLOD1; the disease is Ehlers-Danlos syndrome.