Giving RSV treatment with two dosages (0.1 and 1 mg/kg/day for 7 days) significantly ameliorated the body weight loss, hyperglycemia, hypoinsulinemia, and hyperlipidemia in STZ-DM rats, but the body weight, plasma glucose, insulin, and triglyceride levels in RSV-treated diabetic rats still remained significantly higher in comparison with normal control. This evidence concerns the gene INS and Hypoinsulinemia.