When treated with APS (200 μg/ml) for 24 h ex vivo, the intranuclear Foxp3 protein, Foxp3 mRNA expressions and IL-10 secretion of CD4+CD25+Tregs isolated from burn plus infection mice on PBD 3 and 7 were obviously lower than those in untreated burn plus infection mice on PBD 3 and 7 (P<0.05). The gene discussed is CD4; the disease is infection.