In conclusion, we show that transient, self limiting disruption of intestinal epithelium by activation of Notch signaling triggers rapid onset FLD, associated with hepatic induction of Abcd2, and Vldlr, genes associated with fatty acid uptake, mild insulin resistance and granuloma formation (Figure 6), but that this phenotype is significantly improved 16 days post induction (Figure S3). Here, ABCD2 is linked to Insulin resistance.