However, disruption of IFN-β-signalling failed to inhibit IRF-3 translocation to the nucleus in response to MVA infection in HeLa cells (transfected with siRNA against IFNAR) or macrophages (from IFNAR-deficient mice) (Supplementary Figure S9A, S9D and S9E). The gene discussed is IFNAR1; the disease is mevalonic aciduria.