However, it is remarkable that even at 9-weeks of age when on a chow diet, D2KO mice have higher fasting glucose levels and an increased HOMA index (Table 1), and also have greater insulin levels during GGT and a decreased glucose uptake during ITT (Fig. 3, 4), all consistent with insulin resistance of D2KO even prior to increased weight gain. This evidence concerns the gene INS and Insulin resistance.