In another very recent study, Senapati et al. described that binding of exogenous Gal-3 to MUC4 on the cell surface of CD18/HPAF pancreatic cancer cells enhanced the attachment of the cancer cells to HUVEC endothelial cells in in vitro assays, speculating that MUC4/Gal-3 interaction may facilitate extravasation and metastasis of tumor cells in vivo[41]. This evidence concerns the gene ITGB2 and familial pancreatic carcinoma.