While Honjo et al. report loss of (serum-independent) proliferative capacity and abrogation of anchorage-independent growth in breast cancer cells following silencing of Gal-3 expression [26], Matarrese et al. did not observe any difference in cell growth or proliferation upon modulation of Gal-3 expression, but describe enhanced resistance to apoptosis following overexpression of Gal-3 [36]. The gene discussed is LGALS3; the disease is breast cancer.