The purpose of this study was thus to experimentally evaluate the effects of overexpression or knockdown of Gal-3 in a comprehensive set of pancreatic cancer cell lines (PaTu 8988s, PaTu 8988t, S2-007, S2-028, IMIM-PC-1 and MIA PaCa-2). This evidence concerns the gene LGALS3 and familial pancreatic carcinoma.