Bacterial population studies have suggested the association of the genotype IS1016+, hia+, hmw− with NTHi invasive isolates [41], the presence of the IS1016-bexA deletion with non-type b H. influenzae[39], and the association of lic2B+, hmw+ and nine other genomic loci with NTHi otitis media isolates [37]. Here, CFAP97 is linked to otitis media.