These SNPs showed significant gene-dose effects in the linear trend test and were significantly associated with an increased risk of gastric cancer (OR = 2.83, [95% CI: 1.42–5.65] for ERK rs5999749; OR = 1.90, [95% CI: 1.18–3.05] for Dock180 rs9418677). The gene discussed is EPHB2; the disease is gastric cancer.