GRM5 and keratinization disease: Among the most extreme parallel divergent genes (observed at a threshold of 0.5%) were the skin keratinization gene ABCA12[27] (Figure 6); SH2B1, which controls serum letpin levels and body weight [28]; GRM5, a glutamate receptor associated with schizophrenia [29] and with pigmentation via the closely linked TYR[30]; ATP2A2, which causes a neuropsychiatric/keratinization disorder [31]; F13A1, a coagulation factor linked to numerous cardiovascular diseases and to Alzheimer's [32]; and IFIH1, associated with antiviral defense, type 1 diabetes, and psoriasis [33]–[35] (Figure S2).