MYH9 and focal segmental glomerulosclerosis: This observation suggested that the subset of ESRD cases homozygous for the E1 haplotype differed from non-E1 homozygotes as to their etiology of ESRD and is supported by the observation that biopsy-proven FSGS can be present in AA with T2DM and heavy proteinuria in individuals homozygous for the MYH9 E1 risk haplotype [12].