FRMD3 and Nephropathy: For example, the 4.1 protein ezrin, radixin, moesin [FERM] domain containing 3 locus (FRMD3) was implicated in kidney disease attributed to type 1 diabetes (T1DM) in European Americans from the Genetics of Kidneys in Diabetes (GoKinD) collection, with replication based upon nephropathy progression rates in subjects with T1DM in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study [17].