In addition, significant interactions for MYH9 were not observed with these 5 FRMD3 SNPs in an independent NIH series of 283 biopsy-proven FSGS and HIVAN cases vs. 222 non-nephropathy controls, suggesting the effects are limited to T2DM-ESRD (data not shown). This evidence concerns the gene MYH9 and type 2 diabetes mellitus.