These SNPs in FRMD3 were all in high linkage disequilibrium (LD; Yoruban r2 = 0.95–1.0; CEU r2 = 1.0) and appeared to confer protective effects against T2DM-ESRD in MYH9-E1 risk homozygotes, despite having significant risk effects in non-E1 homozygotes. The gene discussed is MYH9; the disease is type 2 diabetes mellitus.