A number of mutant genes have been identified that predispose to FTAAD, including MYH11 (MIM 160745), ACTA2 (MIM 100678), TGFBR2 (MIM 190182), TGFBR1 (MIM 190181) and MYLK (MIM 600922) [17]–[21]. Here, MYH11 is linked to familial thoracic aortic aneurysm and aortic dissection.