For example, the SIRT1 inhibitor Melatonin inhibits prostate cancer progression in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice [45], Cambinol partly blocks lymphoma development in nude mice [23], Tenovin-6 suppresses breast cancer and melanoma cell proliferation in vitro and blocks melanoma progression in nude mice [24], and Salermide induces dramatic apoptosis in human colon and breast cancer cells [46]. The gene discussed is SIRT1; the disease is melanoma.