SIRT1 and neuroblastoma: As the most common mechanism through which SIRT1 blocks cell death is deacetylation of p53 protein, we hypothesize that repression of SIRT1 does not induce significant cell death in BE(2)-C and LAN-1 cells, because p53 is mutated and N-Myc does not modulate cell survival/death in the neuroblastoma cells [21], [22].