SIRT1 and neuroblastoma: As shown in Figure 1A, N-Myc siRNA-1 and N-Myc siRNA-2 also significantly reduced N-Myc mRNA and protein expression in MYCN-amplified LAN-1 human neuroblastoma cells, and SIRT1 siRNA-1 and SIRT1 siRNA-2 knocked down SIRT1 mRNA and protein expression in both BE(2)-C and LAN-1 cells.