MYCN and neoplasm: Moreover, Cambinol up-regulates MKP3 gene expression in both neuroblastoma and pre-cancerous cells, but not in counterpart normal cells, preventative therapy with Cambinol reduces tumorigenesis in N-Myc transgenic mice, and therapy with Tenovin-6 reduced tumour progression in neuroblastoma-bearing N-Myc transgenic mice in association with reduced N-Myc protein expression and increased MKP3 protein expression in tumor tissues.