PITX3 and lens disorder: In addition to crystallins, expression of the transcription factors Foxe3[18]–[20] and Prox1[19] as well as the cell cycle regulator p57KIP2[19] were found to be affected in Pitx3-deficient animals, which seems more likely to be related to the overall abnormal lens development in aphakia mice rather than direct involvement of Pitx3 in transcriptional regulation of these genes [19].