Two recent publications provided additional data on this matter; Ho and colleagues detected precocious activation of both β- and γ-crystallins in the eyes of 10.5–11.5-dpc Pitx3–knockout mice [18] while Medina-Martinez and coauthors reported deregulation of crystallin expression in aphakia mice with α- and β- crystallin expression being reduced at both transcript and protein levels and γ –crystallin expression being downregulated at the protein level [19]. Here, PITX3 is linked to congenital primary aphakia.