TROP-2 [16], SURF1 [17], SLC2A1 [18], TRIM21 [19], myomegalin [21], UBE2I [22], AISEC [23], CUEC-23 [24] and makorin1 [25] are novel tumor marker SEREX antigens of esophageal SCC. The gene discussed is SURF1; the disease is esophageal squamous cell carcinoma.