TROP-2 [16], SURF1 [17], SLC2A1 [18], TRIM21 [19], myomegalin [21], UBE2I [22], AISEC [23], CUEC-23 [24] and makorin1 [25] are novel tumor marker SEREX antigens of esophageal SCC. This evidence concerns the gene TRIM21 and esophageal squamous cell carcinoma.