CHI3L1 and type 1 diabetes mellitus: YKL-40 levels are elevated both in patients with T1D and T2D known to be at high risk for the development of cardiovascular diseases [10-12], and in patients with T1D increasing levels of YKL-40 are seen with increasing levels of albuminuria, suggesting that YKL-40 might be able to be used as an early marker of CVD [11].