VDR and Insulin resistance: This study pursues three objectives: Firstly, to tackle relationship between VDR genotypes and T2DM for the first time in Iranian population; secondly, to elucidate the potential mechanisms and cross-talk among pathways, by which vitamin D exerts its effects on diabetes, insulin resistance and cardiovascular disease by evaluating an extensive panel of biomarkers (anthropometric, metabolic, inflammatory and oxidative stress); and finally to identify vitamin D responsive vs. less or (maybe) non-responsive VDR genetic variants in subjects with T2DM for further proper nutritional care.