PRRT2 and cancer: Purine metabolism–the most significantly associated pathway–has been observed to be altered in cancer cells [39], [40], and the majority of the other significant pathways are directly related to cell migration (e.g., ErbB signaling and gap junction pathways) and cellular signalling (e.g., calcium signaling, PKC-catalyzed phosphorylation of myosin phosphatase, attenuation of GPCR signaling, and activation of PKC through GPCRs) processes that have been implicated in a variety of cancers.