As PI3K/Akt signaling pathway plays a critical role in the activation and immune responses of eosinophils, T and B lymphocytes, and mast cells [18], [19], [20], and genetic ablation of PI3Kδ or PI3Kγ isoform in mice has been shown to dampen Th2 immune responses, eosinophilic lung infiltration, and airway hyperresponsiveness and remodeling [21], [22], [23], we investigated the effects of artesunate on various aspects of ovalbumin (OVA)-induced Th2-mediated allergic airway inflammation in an in vivo mouse asthma model and explored the anti-inflammatory mechanism of action of artesunate. This evidence concerns the gene PIK3CD and asthma.