PTEN and neoplasm: To examine whether PTEN deletion could affect tumor progression in Amhr2-Cre;Ctnnb1Δ(ex3)/+ ovaries, we developed another mouse model by deleting exon 3 of the β-catenin in PTEN negative cells of the mouse ovary (Amhr2-Cre;Ctnnb1Δ(ex3)/+;PtenΔ/Δ) (Fig. 3C & F).