Given the well documented role of IFNα/β in the pathogenesis of autoimmune disorders (including systemic lupus erythematosus, psoriasis, and Type 1 diabetes mellitus [17], [18], [19], [20]), temporal downregulation of IFNAR1 might play an important role in protecting the host from such autoimmune reactions. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.