TM40D (CD1d-hi) tumor cells demonstrated increased cytotoxicity over TM40D-MB (CD1d-lo) tumor cells in a range of effector to target cell ratios, and significantly higher cytotoxicity at an E:T ratio of 25∶1 (P<0.05), as measured by the release of lactate dehydrogenase (LDH) (Fig. 2B). The gene discussed is CD1D; the disease is neoplasm.