Both the TM40D and TM40D-MB tumor groups had decreased splenic levels of CD4+ and CD8+ T cell populations as compared to unchallenged mice, although the reduction in the TM40D-MB group was significantly more pronounced (CD4+P = 0.003, CD8+P = 0.012) (Fig. 3B,D). The gene discussed is CD8A; the disease is neoplasm.