Type I NKT dominant tumors, such as 4T1 mammary carcinoma and CT26 colon carcinoma, have been shown to grow similarly in CD1d KO (type I and II deficient) and Jα18 KO (type I deficient) mice as in wildtype, but demonstrate increased metastasis in Jα18 KO mice [37]. Here, CD1D is linked to colon carcinoma.