However, while the CD1d-deficient 4T1-implanted CD1d KO mice exhibited fewer metastases and increased survival as compared to Jα18 KO mice, our CD1d-expressing TM40D tumor cells showed the opposite effect, with significantly increased metastasis in the CD1d KO mice as compared to Jα18 KO mice. The gene discussed is CD1D; the disease is neoplasm.