Therefore, it was thought that the major role of EVI1 in hematopoietic transformation was based on inappropriate interactions with factors and cytokines that monitor cell growth and differentiation in a way similar to that proposed for leukemia-associated and hematopoiesis-specific factors such as RUNX1 or GATA1 or PU.1 [28]–[30]. Here, SPI1 is linked to leukemia.