Interestingly, FSHD-1 and FSHD-2 cells showed the common deregulation of five genes involved in cholesterol metabolic process; four genes (HMGCR, DHCR7, DHCR24 and IDI1) implied in cholesterol biosynthesis, were up-regulated in FSHD-1 and down-regulated in FSHD-2, and one gene (ABCA1) involved in the efflux of cholesterol from the cell, was down-regulated in FSHD-1 and upregulated in FSHD-2. This evidence concerns the gene ABCA1 and facioscapulohumeral muscular dystrophy.