The found deregulation of SOD2 in FSHD-1 myoblasts and of glutathione reductase (GSR) and peroxidase (GPX4) in FSHD-2 myotubes could suggest for both FSHD manifestations the occurrence of a similar increased susceptibility to oxidative stress. The gene discussed is SOD2; the disease is facioscapulohumeral muscular dystrophy.