KCNMA1 and Osteopenia: To study the functional relevance of osteoclast BK channel in bone in vivo and to evaluate its impact for juvenile osteopenia, we analyzed juvenile female wild-type (WT) and BK-deficient (BK−/−) mice [17] using in vitro and in vivo assays, flat-panel volumetric computed tomography (fpVCT) [28], [29] as well as high-resolution micro-CT (μCT).