KCNMA1 and osteosarcoma: Patch-clamp experiments using cultured chicken osteoclastic cells [21] as well as the osteoblastic human osteosarcoma cell lines MG-63 [22]–[24] and SaOS-2 [22], and the human osteogenic precursor cell line C1 [25] revealed the existence of a large conductance Ca2+-activated K+ channel in these cell types in vitro, which was assumed to be BK channel.